# DSIP References: The Cited Literature

> DSIP references: the full source list behind this site — PubMed-indexed studies on the delta sleep-inducing peptide, with PMIDs and DOIs. Every claim traces here.

Fifteen sources. Every [N] on this site resolves here. PMID and DOI where available.

## About this list

These DSIP references are the complete source list for this site. Every numbered citation in the text resolves to an entry here. Sources are PubMed-indexed studies and reviews; identifiers are given as PMIDs and DOIs so each can be located directly. The literature is animal-heavy, the human work is small and mostly from the 1980s, and no modern randomized controlled trial exists — the list reflects that. Where a community claim could not be tied to a source on this list, the text states it without a citation number.

## References

[1] Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977;74(3):1282-1286. https://pubmed.ncbi.nlm.nih.gov/265572/
[2] Schneider-Helmert D, et al. The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep. Experientia. 1981;37(8):913-914. https://pubmed.ncbi.nlm.nih.gov/7028502/
[3] Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. https://pubmed.ncbi.nlm.nih.gov/16539679/
[4] Bjartell A, Ekman R, Bergquist S, Widerlov E. Reduction of immunoreactive ACTH in plasma following intravenous injection of delta sleep-inducing peptide in man. Psychoneuroendocrinology. 1989;14(5):347-355. https://pubmed.ncbi.nlm.nih.gov/2554357/
[5] Popovich IG, Voitenkov BO, Anisimov VN, et al. Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. Mech Ageing Dev. 2003;124(6):721-731. https://pubmed.ncbi.nlm.nih.gov/12782416/
[6] Mu X, Qu L, Yin L, Wang L, Liu X, Liu D. Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models. Front Pharmacol. 2024;15:1439536. https://pubmed.ncbi.nlm.nih.gov/39444618/
[7] Khvatova EM, et al. Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia. Peptides. 2003;24(2):307-311. https://pubmed.ncbi.nlm.nih.gov/12668217/
[8] Popovich IG, Anisimov VN, et al. Effect of delta-sleep inducing peptide preparation Deltaran on longevity, physiological functions, and carcinogenesis in mice. Adv Gerontol. 2009;22(1):57-65. https://pubmed.ncbi.nlm.nih.gov/20405733/
[9] Bondarenko TI, et al. Mechanism of delta-sleep inducing peptide geroprotective activity. Adv Gerontol. 2011;24(2):279-285. https://pubmed.ncbi.nlm.nih.gov/21809625/
[10] Shmal'ko IuP, Mikhaleva II. [Antimetastatic effect of the delta-sleep peptide during stress in mice with Lewis' lung carcinoma]. Eksperimental'naia onkologiia. 1988;10:57-60. https://pubmed.ncbi.nlm.nih.gov/2899023/
[11] Khvatova EM, Rubanova NA, Prudchenko IA, Mikhaleva II. Effects of delta-sleep inducing peptide (DSIP) and some analogues on the activity of monoamine oxidase type A in rat brain under hypoxia stress. FEBS Letters. 1995;368:367-369. https://pubmed.ncbi.nlm.nih.gov/7628639/
[12] Bjartell A, Castro MG, Ekman R, Sundler F, Widerlöv E, Loh YP. Immunoreactive delta sleep-inducing peptide secretion from mouse dissociated, anterior pituitary cells: regulation by corticotropin-releasing factor and arginine vasopressin. Neuroendocrinology. 1989;50:564-569. https://pubmed.ncbi.nlm.nih.gov/2558325/
[13] Bjartell A, Ekman R, Hedenbro J, Sjölund K, Sundler F. Delta sleep-inducing peptide (DSIP)-like immunoreactivity in gut: coexistence with known peptide hormones. Peptides. 1989;10:163-170. https://pubmed.ncbi.nlm.nih.gov/2664725/
[14] Ahlman H, Ahlund L, Nilsson O, Dahlström A, Bjartell A, Ekman R. Coexistence of delta sleep-inducing peptide and serotonin in midgut carcinoid tumour cells in vivo and in vitro. International Journal of Cancer. 1989;44:641-647. https://pubmed.ncbi.nlm.nih.gov/2793237/
[15] Lesch KP, Widerlöv E, Ekman R, et al. Delta sleep-inducing peptide response to human corticotropin-releasing hormone (CRH) in major depressive disorder. Comparison with CRH-induced corticotropin and cortisol secretion. Biological Psychiatry. 1988;24:162-172. https://pubmed.ncbi.nlm.nih.gov/2839244/

---

A dark readout of the DSIP literature — every finding counted and cited, nothing prescribed and nothing sold.